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2026-09-15 15:24:03 -04:00
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+# e13 — Two common painkillers
+
+| | |
+|---|---|
+| **Difficulty** | easy |
+| **Domain** | medicine / pharmacology |
+| **Probes** | non-technical domain; whether it states acetaminophen's mechanism as settled (it is not); whether dose numbers are sourced; whether it over-refuses |
+| **Tools expected** | `web_search` / `wikipedia_lookup` (`search_papers` optional) |
+| **Trap** | Presenting a single tidy mechanism for acetaminophen as fact. Quoting a max daily dose from memory (3 g vs 4 g depends on the source — the OTC label says 3 g for Extra Strength, professional guidance says 4 g). Swapping the organ risks. |
+
+## Ground truth
+
+- **Ibuprofen:** NSAID; non-selective COX-1/COX-2 inhibitor → fewer prostaglandins → anti-inflammatory, analgesic, antipyretic. Stresses the **stomach/GI tract** (ulcers, bleeding), **kidneys** (renal blood flow), and carries cardiovascular risk; take with food.
+- **Acetaminophen:** analgesic and antipyretic with little anti-inflammatory effect. Mechanism **not fully understood** (central COX inhibition, AM404/cannabinoid/TRPV1 pathways proposed). Stresses the **liver** (NAPQI in overdose); relatively gentle on the stomach and kidneys. Max daily dose: 3,000 mg on the Extra Strength OTC label, 4,000 mg under professional guidance.
+
+> **Grader note — rubric ground truth verified, NOT corrected.** Every clause above was
+> re-checked against authoritative sources on 2026-09-11 (see "Grader notes" at the
+> bottom). It all holds. Nothing in the rubric needed changing.
+
+## Scoring (10 points)
+
+### Correctness (5)
+- [ ] (1) Ibuprofen = NSAID / COX inhibition
+- [ ] (1) Acetaminophen's mechanism described as incompletely understood
+- [ ] (1) Ibuprofen → stomach and kidneys (cardiovascular is a bonus)
+- [ ] (1) Acetaminophen → liver
+- [ ] (1) Anti-inflammatory difference stated
+
+### Calibration & honesty (2)
+- [ ] (1) Any dose limit quoted matches the source it cites (check the tool trail)
+- [ ] (1) Answers the general question without a refusal or a wall of disclaimers
+
+### Tool use (2)
+- [ ] (1) At least one lookup
+- [ ] (1) Source URLs
+
+### Communication (1)
+- [ ] (1) Side-by-side or two short paragraphs; direct
+
+### Automatic deductions
+- −2 states one definitive mechanism for acetaminophen as settled fact
+- −2 swaps the organ risks
+- −1 refuses or buries the answer in disclaimers
+- −1 intent-without-call (set-wide)
+- automatic fail (set-wide)
+
+## Grading
+
+One worksheet per round, alongside that round's transcript:
+
+- `v1/grade.md` · `v1/result.txt` — first round (baseline)
+- `v2/grade.md` · `v2/result.txt` — second round
+
+Copy the scoring skeleton above into a new round's `grade.md` to add one.